Kerala is experiencing a rising cancer burden driven by demographic transitions and unhealthy lifestyle patterns. Recognising the urgent need to address these challenges, the Association of Medical and Paediatric Oncologists of Kerala conducted a comprehensive survey to evaluate public awareness regarding cancer risk factors, prevention strategies and screening practices. The survey, conducted between October and December 2024, employed a mixed-method approach using online and door-to-door data collection to ensure inclusivity across diverse demographic groups. The findings revealed a high general awareness of cancer symptoms and risk factors. However, significant gaps persisted in knowledge about preventive measures such as vaccination and genetic testing. Despite heightened awareness, screening rates remained low. The survey findings underscore the importance of tailored educational interventions to address misconceptions, promote preventive behaviours and enhance access to affordable screening and treatment services. Lessons from this study hold relevance for global oncology programs, offering opportunities for bidirectional learning to enhance cancer awareness and prevention initiatives worldwide.